Messenger RNA science

mRNA design, manufacture and research

About BASE

The BASE facility, at The University Of Queensland, is a global leader in mRNA research and manufacture.

We help scientists develop new mRNA medicines. We have experience building mRNA for a wide range of clinical applications.

We provide end-to-end research services to design, manufacture and test new mRNA medicines.

mRNA research

BASE is a global leader in mRNA research. Our scientists are leading innovative research programs in:

mRNA discovery and development
Bioinformatic design and NGS analysis of mRNA
Cell-free, isothermal mRNA production
mRNA cancer vaccines

mRNA design

BASE scientists have experience designing mRNAs for a wide range of clinical applications.

Our software toolkit, mRNArchitect, can optimise your mRNA sequences for expression, stability and immunogenicity.

We have also assembled a catalog of validated elements, including UTRs, localisation and signal peptides.

mRNA products

Off-the-shelf mRNA

Small-scale custom mRNA for in vitro studies.

Best choice for cell culture experiments.
Custom mRNA made to spec.
mRNA design (CDS & UTR)
DNA template synthesis.
in vitro transcription and purification.
Analytical report.
Ready for transfection into cell culture.

Large-scale custom mRNA for in vivo studies

Custom mRNA Services

BASE can manufacture mRNA medicines according to your specification, including:

Sequence design
mRNA manufacture
LNP formulation
QC Analysis

Our mRNA and LNPs is carefully tested to ensure high quality, purity and performance.

Developing mRNA medicines

We can help develop mRNA medicines from discovery, pre-clinical through to early clinical outcomes. We can tailor our research services to your requirements, including:

Expert mRNA design and in vitro screening
High-quality mRNA + LNP production with detailed analytics
In vivo testing of mRNA delivery and efficacy

Enquiries

Our support team is available to help with your mRNA projects.