Translating mRNA into medicines

We help scientists build the next generation of mRNA medicines.

BASE is one of Australia’s leading facilities for the development of mRNA–LNP medicines.

We have established a high-quality mRNA–LNP platform validated across a wide range of experiments, cell types, and tissues. Our team has experience supporting programs in vaccines, cancer, protein replacement, immunotherapies, antibodies, and gene and cell therapies.

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Our mRNA-LNP platform

Our platform

mRNA design

• mRNArchitect optimisation for best-in-class expression and stability.

• Validated catalogue of mRNA elements, including UTRs, SPs, TMs etc.

• Design reports with predicted performance for review and approval.

mRNA synthesis

• We supply high-quality mRNA for research use.

• We can design custom mRNA to your precise specifications.

• Pre-made and pre-validated mRNA controls.

• All batches provided with detailed QC report.

LNP formulation

• We can formulate mRNAs within standards and custom LNP formulations.

• Targeted LNPs for delivery to specific cell and tissue types.

• All batches evaluated with detailed QC report.

• Useful protocols, dosage and administration advice.

Learn to make mRNA medicines

Practical guides to the design, manufacture and formulation of mRNA medicines.

Access our resources and protocols, including a step-by-step guide to making high-quality mRNA-LNP medicines using standard equipment within a research laboratory.

Access our protocols

Latest news from BASE

4th QLD mRNA Symposium

On International RNA Day (1 August), the BASE facility hosted the 4th QLD mRNA Symposium, bringing together leading experts from research, clinical, government, and industry to discuss advances in mRNA medicines.

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mRNA-LNP masterclass

Our graduates successfully completed the first Winter mRNA Masterclass, a week-long intensive program that trains students in the science, computational design, and laboratory production of mRNAs and LNPs.

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Our workflow published

We published our step-by-step protocol for mRNA-LNP production, describing the design, manufacture, and quality control of mRNA medicines using standard equipment in a research laboratory.

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About Us

We are a team of scientists passionate about mRNA

The BASE facility works with scientists around the world to build new mRNA medicines.

We are located at the Australian Institute for Bioengineering and Nanotechnology, University of Queensland. BASE is proudly supported by Therapeutic Innovation Australia (TIA), and is part of Australia’s National Critical Research Infrastructure (NCRIS).

Our story

Partners

We have supported more than 250+ research laboratories worldwide.

Our partners

Research and innovation

A better understanding of mRNA-LNP medicines.

BASE scientists lead an ambitious research program developing new mRNA technologies and medicines.

Combining computational biology, molecular science, pharmacology, and clinical research, we help scientists advance promising mRNA medicines from early discovery through preclinical development.

Our research

mRNA-LNP products and services

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Custom mRNA

• Custom mRNA produced according to your specifications.

• Our team has experience across many applications, including vaccines, protein replacement, gene therapies, and cell therapies.

• From small scale batches for pilot experiments, to large-scale for pre-clinical studies.

Off-the-shelf mRNA

• Pre-made and pre-validated mRNA ready for use in your experiments.

• Useful mRNAs reporters and controls, including eGFP, luciferase, Cas9, Ovalbumin etc.

• Validated for strong expression and performance.

• Available for immediate shipment.

LNP formulation

• Experience in hundreds of LNP formulations.

• All mRNA-LNP batches supported by comprehensive quality control.

• Targeted LNPs for delivery to specific cell and tissue types.

• Protocols for in vivo dosage and administration available.

mRNA training and courses

Advance your skills in mRNA science.

Access our protocols, webinars and resources to build your expertise – whether you are an early-career researcher or an experienced industry scientist.

The BASE facility also provides hands-on training in the design, manufacture and delivery of mRNA medicines. We also provide study opportunities at BASE, including higher degree (Masters, PhD) research programs.

Training programs

Enquiries

Our team is available to help with your mRNA projects.