BASE FACILITY

mRNA science at the University of Queensland

• The BASE facility is building the next generation of mRNA vaccines and therapies.

• We have a successful track record manufacturing dozens of mRNAs according to the requirements of our scientific, clinical and industry partners.

• We can help develop your mRNA vaccines and therapies – from design, manufacture, and pre-clinical research through to clinical trials.

• We provide off-the-shelf or custom mRNA tailored according to your requirements (n1-methyl-psuedouridine, 5’ CleanCapAG, lipid nanoparticle formulation)

• We have experience providing affordable high-quality mRNA, reliable customer service, fast turn-around times and shipping across Australia.

• Access the latest mRNA technologies and adjacent, world-class research services at the University of Queensland (pre-clinical research, animal facilities, clinical trials).

1.

Off-the-shelf mRNA

  • Free for pilot studies (~100ug), immediate dispatch
  • Common mRNA reagents, including eGFP, luciferase, mCherry, CRISPR etc.
  • Rapid and inexpensive scale-up for larger projects (>2mg)
  • Can formulate mRNA reagents into LNPs (PNI)
  • All of our mRNA reagents have been experimentally validated.

2.

Small-scale custom mRNA for in vitro studies

  • ~100ug high quality mRNA, 4-6 weeks
  • Best choice for cellular experiments.
  • mRNA design (optimised, UTRs etc.)
  • Medium-scale plasmid synthesis and preparation.
  • mRNA synthesis and purification (~100ug)
  • Supporting analytical report (HPLC, tapestation etc.)
  • Ready for transfection into your favourite cell type using standard methods (messengerMAX, electroporation etc.).
  • Higher expression and efficiency, even in difficult cells.

3.

Large-scale custom mRNA for in vivo studies

  • ~4 mg high-quality mRNA, 6-8 weeks
  • Best choice for animal studies.
  • mRNA design (optimised, UTRs etc.)
  • Large-scale plasmid synthesis and preparation.
  • mRNA synthesis and purification (~4mg)
  • Lipid-nanoparticle formulation (PNI)
  • Extended analytical report (HPLC, tapestation, NGS, LNP size, protection etc.)
  • Ready for delivery into your favourite mouse model.

BASE is a non-profit research services facility located at the Australian Institute for Bioengineering and Nanotechnology (AIBN), the University of Queensland (UQ).

BASE is a joint initiative with the National Biologics Facility (NBF) and Protein Expression Facility (PEF), and is proudly supported by Therapeutics Innovation Australia (TIA).