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Messenger RNA science

mRNA design, manufacture and research

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About BASE

The BASE facility, at The University Of Queensland, is a global leader in mRNA research and manufacture.

We help scientists develop new mRNA medicines. We have experience building mRNA for a wide range of clinical applications.

We provide end-to-end research services to design, manufacture and test new mRNA medicines.

mRNA services
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mRNA research

BASE is a global leader in mRNA research. Our scientists are leading innovative research programs in:

  • mRNA discovery and development
  • Bioinformatic design and NGS analysis of mRNA
  • Cell-free, isothermal mRNA production
  • mRNA cancer vaccines
mRNA research
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mRNA design

BASE scientists have experience designing mRNAs for a wide range of clinical applications. 

Our software toolkit, mRNArchitect, can optimise your mRNA sequences for expression, stability and immunogenicity.

We have also assembled a catalog of validated elements, including UTRs, localisation and signal peptides. 

Design your mRNA

mRNA products

Off-the-shelf mRNA

  • Best choice for pilot studies and useful controls.
  • Common mRNAs (eGFP, luciferase, ovalbumin etc.)
  • Optional formulation within LNPs.
  • Our mRNAs have been experimentally validated.

Small-scale custom mRNA for in vitro studies.

  • Best choice for cell culture experiments.
  • Custom mRNA made to spec.
  • mRNA design (CDS & UTR)
  • DNA template synthesis.
  • in vitro transcription and purification.
  • Analytical report.
  • Ready for transfection into cell culture.

Large-scale custom mRNA for in vivo studies

  • Best choice for animal studies.
  • Custom large - scale mRNA manufacture and purification.
  • Lipid nanoparticle (LNP) formulation.
  • QC Analysis
  • Ready for delivery into in vivo models.
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Custom mRNA Services

BASE can manufacture mRNA medicines according to your specification, including:

  • Sequence design
  • mRNA manufacture
  • LNP formulation
  • QC Analysis

Our mRNA and LNPs is carefully tested to ensure high quality, purity and performance.

mRNA services
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Developing mRNA medicines

We can help develop mRNA medicines from discovery, pre-clinical through to early clinical outcomes. We can tailor our research services to your requirements, including:

  • Expert mRNA design and in vitro screening
  • High-quality mRNA + LNP production with detailed analytics
  • In vivo testing of mRNA delivery and efficacy
mRNA development services

Enquiries

Our support team is available to help with your mRNA projects.

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Research Laboratories

Level 3, AIBN (#75)
The University of Queensland
St Lucia, QLD 4072

Manufacture Facility

Level 6, Translational Research Institute
37 Kent St
Woolloongabba, QLD 4102

Email

base@uq.edu.au

Phone

+61 7 3443 7368

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