BASE scientists drive research into novel applications of synthetic nucleic-acids.


RNA therapies.

The translation of proteins from synthetic mRNA vaccines can initiate an adaptive immune response, and confer immune protection. mRNA vaccines have proven effective vaccines to protect against COVID-19, and hold incredible potential to protect against infectious disease and cancer.

The BASE facility specialises in the production in mRNA vaccines for use in research and pre-clinical studies.

Synthetic biology.

Combining biology with engineering principles allows the design and construction of biological systems. This includes the design of nucleic-acids sensors, switches and circuits in cell-free systems.  By editing and re-designing genes, we can engineer organisms with new functions to address current and future challenges.

BASE scientists research the design, synthesis and assembly of new genes for use in synthetic biology applications.


Synthetic DNA probes and primers are widely used in a range of biotechnologies and genome-wide analysis. This includes the development of CRISPR screens, oligonucleotide capture methods, and in situ hybridisation approaches.

BASE scientists use a wide range of synthetic nucleotide technologies in genome sequencing and analysis.